Beilstein J. Org. Chem.2013,9, 2940–2949, doi:10.3762/bjoc.9.331
the cis-isomer allowing us to suggest a 7,8-erythro relative stereochemistry.
The application of the doublederivatization method with a chiral auxiliary reagent developed by Riguera [30] allows for the confirmation of the relative configuration at C-7 and C-8 and the assignment of the absolute
the doublederivatization method with a chiral auxiliary reagent and the results were fully in agreement with the relative configuration of the epoxide moiety on the plakilactone H side chain. Subsequently, the absolute configuration at C-4 and C-6 was obtained through QM calculations of 13C chemical
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Graphical Abstract
Figure 1:
Plakilactones G and H, new oxygenated polyketides from Plakinastrella mamillaris, and their congene...
Beilstein J. Org. Chem.2013,9, 516–525, doi:10.3762/bjoc.9.56
or iodides, yielding novel optically active ionic liquids. Racemic salts were tested against a wide range of microorganisms.
Keywords: antibiotics; antifungal agents; doublederivatization; enzyme catalysis; ionic liquids; Introduction
Aromatic heterocycles play a crucial role in medicinal
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Graphical Abstract
Scheme 1:
Synthesis of optically active ILs. Reagents and conditions: (i) 1,2-propylene oxide (1.1 equiv), 32...